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Visualizing similarities between human insulin and bovine insulin in Chem3D

Use ChemBio3D's "fast overlay" function for proteins up to the size of an insulin chain.

Presenter: Jesse Gordon
Company: PerkinElmer Informatics
Duration: 5 Min
Issue: 21.3

ChemBio3D's overlay function is best known for small molecule overlay. In this video, we demonstrate that the same method applies to peptides. The demonstration includes:

  • Open our standard sample file for human insulin and remove the water solvent.
  • Download bovine insulin via ChemBio3D's online PDB ID lookup for ID=2ZP6.
  • Paste the human insulin into the same ChemBio3D object as the bovine insulin.
  • Select chain A from the bovine insulin as the "Target Fragment".
  • Apply "Fast Overlay" to chain A from the human insulin.
  • Observe that the primary structures for the two fragments are identical, but the tertiary structures differ.
  • Show the human chain B and bovine chain B; they have been loosely overlaid along with the chain A's.


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  • ChemBio3D object containing human insulin overlaid with bovine insulin

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